Ontology highlight
ABSTRACT:
SUBMITTER: Pautus S
PROVIDER: S-EPMC5120274 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Pautus Stéphane S Alami Mouad M Adam Fréderic F Bernadat Guillaume G Lawrence Daniel A DA De Carvalho Allan A Ferry Gilles G Rupin Alain A Hamze Abdallah A Champy Pierre P Bonneau Natacha N Gloanec Philippe P Peglion Jean-Louis JL Brion Jean-Daniel JD Bianchini Elsa P EP Borgel Delphine D
Scientific reports 20161123
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the tissue type and urokinase type plasminogen activators. High levels of PAI-1 are correlated with an increased risk of thrombotic events and several other pathologies. Despite several compounds with in vitro activity being developed, none of them are currently in clinical use. In this study, we evaluated a novel PAI-1 inhibitor, annonacinone, a natural product from the Annonaceous acetogenins group. Annonacinone was identified ...[more]