Ontology highlight
ABSTRACT:
SUBMITTER: Brenan L
PROVIDER: S-EPMC5120861 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Brenan Lisa L Andreev Aleksandr A Cohen Ofir O Pantel Sasha S Kamburov Atanas A Cacchiarelli Davide D Persky Nicole S NS Zhu Cong C Bagul Mukta M Goetz Eva M EM Burgin Alex B AB Garraway Levi A LA Getz Gad G Mikkelsen Tarjei S TS Piccioni Federica F Root David E DE Johannessen Cory M CM
Cell reports 20161001 4
Tumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-associated mutants whose biological functions and impacts on therapeutic response are uncharacterized. To begin to address this limitation, we functionally characterized nearly all (99.84%) missense mutants of MAPK1/ERK2, an essential effector of oncogenic RAS and RAF. Using this approach, we discovered rare gain- ...[more]