Ontology highlight
ABSTRACT:
SUBMITTER: Lin Z
PROVIDER: S-EPMC5121000 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Developmental cell 20161006 4
Binding of the transcriptional co-activator YAP with the transcription factor TEAD stimulates growth of the heart and other organs. YAP overexpression potently stimulates fetal cardiomyocyte (CM) proliferation, but YAP's mitogenic potency declines postnatally. While investigating factors that limit YAP's postnatal mitogenic activity, we found that the CM-enriched TEAD1 binding protein VGLL4 inhibits CM proliferation by inhibiting TEAD1-YAP interaction and by targeting TEAD1 for degradation. Impo ...[more]