Ontology highlight
ABSTRACT:
SUBMITTER: Devader C
PROVIDER: S-EPMC5121284 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Devader Christelle C Moreno Sébastien S Roulot Morgane M Deval Emmanuel E Dix Thomas T Morales Carlos R CR Mazella Jean J
Frontiers in neuroscience 20161124
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three different receptors (NTSR1, NTSR2, and NTSR3 also called sortilin). Pharmacological approaches and generation of NTSR1 and NTSR2-deficient mice allowed to determine the NT-induced antipsychotic like behavior, the inhibitory of weak fear memory and the nociceptive signaling in a rat formalin tonic pain model to NTSR1. Conversely, the effects of NT on thermal and tonic nociceptions were mediated by NTSR2. Howe ...[more]