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Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.
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ABSTRACT: Background
We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts.Materials and methods
Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed.Results
Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P > 0.05).Conclusion
Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children.
SUBMITTER: Ebadifar A
PROVIDER: S-EPMC5121989 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20160801
<h4>Background</h4>We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (<i>MTHFR</i> C677T and A1298C) gene polymorphisms in Iranian children with oral clefts.<h4>Materials and methods</h4>Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotype ...[more]