Ontology highlight
ABSTRACT:
SUBMITTER: De Re V
PROVIDER: S-EPMC5122326 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
De Re Valli V De Zorzi Mariangela M Caggiari Laura L Lauletta Gianfranco G Tornesello Maria Lina ML Fognani Elisa E Miorin Marta M Racanelli Vito V Quartuccio Luca L Gragnani Laura L Russi Sabino S Pavone Fabio F Ghersetti Michela M Costa Elena Garlatti EG Casarin Pietro P Bomben Riccardo R Mazzaro Cesare C Basaglia Giancarlo G Berretta Massimiliano M Vaccher Emanuela E Izzo Francesco F Buonaguro Franco Maria FM De Vita Salvatore S Zignego Anna Linda AL De Paoli Paolo P Dolcetti Riccardo R
Oncotarget 20160601 25
To explore the relationship between innate immunity and hepatitis C Virus (HCV) in determining the risk of cirrhosis (CIR), hepatocellular carcinoma (HCC), mixed cryoglobulinemia syndrome (MCS) and non-Hodgkin lymphoma (NHL), we investigated the impact of the toll-like receptor-2 (TLR2) and interleukin-28B (IL28B) genetic variants. TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B ...[more]