Ontology highlight
ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC5122337 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Xu Suowen S Liu Bin B Yin Meimei M Koroleva Marina M Mastrangelo Michael M Ture Sara S Morrell Craig N CN Zhang David X DX Fisher Edward A EA Jin Zheng Gen ZG
Oncotarget 20160601 25
TRPV4 ion channel mediates vascular mechanosensitivity and vasodilation. Here, we sought to explore whether non-mechanical activation of TRPV4 could limit vascular inflammation and atherosclerosis. We found that GSK1016790A, a potent and specific small-molecule agonist of TRPV4, induces the phosphorylation and activation of eNOS partially through the AMPK pathway. Moreover, GSK1016790A inhibited TNF-α-induced monocyte adhesion to human endothelial cells. Mice given GSK1016790A showed increased p ...[more]