Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC5122339 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Yang Zongyuan Z Xu Sen S Jin Ping P Yang Xin X Li Xiaoting X Wan Dongyi D Zhang Taoran T Long Sixiang S Wei Xiao X Chen Gang G Meng Li L Liu Dan D Fang Yong Y Chen Pingbo P Ma Ding D Gao Qinglei Q
Oncotarget 20160601 25
The Cancer Genome Atlas network has revealed that the 'mesenchymal' epithelial ovarian cancer (EOC) subtype represents the poorest outcome, indicating a crucial role of stromal cancer-associated fibroblasts (CAFs) in disease progression. The cooperative role of CAFs in EOC metastasis has long been recognized, but the mechanisms of stromal CAFs activation are still obscure. Therefore, we carried out an integrative analysis to identify the regulator genes that are responsible for CAFs activation i ...[more]