Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC5122358 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Liu Hao H Innamarato Pasquale Patrick PP Kodumudi Krithika K Weber Amy A Nemoto Satoshi S Robinson John L JL Crago Georgina G McCardle Timothy T Royster Erica E Sarnaik Amod A AA Pilon-Thomas Shari S
Oncotarget 20160601 25
Intralesional (IL) therapy is under investigation to treat dermal and subcutaneous metastatic cancer. Rose bengal (RB) is a staining agent that was originally used by ophthalmologists and in liver function studies. IL injection of RB has been shown to induce regression of injected and uninjected tumors in murine models and clinical trials. In this study, we have shown a mechanism of tumor-specific immune response induced by IL RB. In melanoma-bearing mice, IL RB induced regression of injected tu ...[more]