VariancePartition: interpreting drivers of variation in complex gene expression studies.

ABSTRACT:

Background

As large-scale studies of gene expression with multiple sources of biological and technical variation become widely adopted, characterizing these drivers of variation becomes essential to understanding disease biology and regulatory genetics.

Results

We describe a statistical and visualization framework, variancePartition, to prioritize drivers of variation based on a genome-wide summary, and identify genes that deviate from the genome-wide trend. Using a linear mixed model, variancePartition quantifies variation in each expression trait attributable to differences in disease status, sex, cell or tissue type, ancestry, genetic background, experimental stimulus, or technical variables. Analysis of four large-scale transcriptome profiling datasets illustrates that v

SUBMITTER: Hoffman GE 

PROVIDER: S-EPMC5123296 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature