Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA.
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ABSTRACT:
SUBMITTER: Waller ZA
PROVIDER: S-EPMC5123632 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA.
Waller Zoë A E ZA Pinchbeck Benjamin J BJ Buguth Bhovina Seewoodharry BS Meadows Timothy G TG Richardson David J DJ Gates Andrew J AJ
Chemical communications (Cambridge, England) 20161102 92
Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription. ...[more]
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