Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC5123674 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Wang Wei W Erbe Amy K AK Gallenberger Mikayla M Kim KyungMann K Carmichael Lakeesha L Hess Dustin D Mendonca Eneida A EA Song Yiqiang Y Hank Jacquelyn A JA Cheng Su-Chun SC Signoretti Sabina S Atkins Michael M Carlson Alexander A Weiss Jonathan M JM Mier James J Panka David D McDermott David F DF Sondel Paul M PM
Cancer immunology, immunotherapy : CII 20160930 12
NK cells play a role in many cancer immunotherapies. NK cell activity is tightly regulated by killer immunoglobulin-like receptor (KIR) and KIR-ligand interactions. Inhibitory KIR-ligands have been identified as HLA molecules, while activating KIR-ligands are largely unknown. Individuals that have not inherited the corresponding KIR-ligand for at least one inhibitory KIR gene are termed the "KIR-ligand missing" genotype, and they are thought to have a subset of NK cells that express inhibitory K ...[more]