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Association of Specific Dietary Fats With Total and Cause-Specific Mortality.


ABSTRACT: IMPORTANCE:Previous studies have shown distinct associations between specific dietary fat and cardiovascular disease. However, evidence on specific dietary fat and mortality remains limited and inconsistent. OBJECTIVE:To examine the associations of specific dietary fats with total and cause-specific mortality in 2 large ongoing cohort studies. DESIGN, SETTING, AND PARTICIPANTS:This cohort study investigated 83?349 women from the Nurses' Health Study (July 1, 1980, to June 30, 2012) and 42?884 men from the Health Professionals Follow-up Study (February 1, 1986, to January 31, 2012) who were free of cardiovascular disease, cancer, and types 1 and 2 diabetes at baseline. Dietary fat intake was assessed at baseline and updated every 2 to 4 years. Information on mortality was obtained from systematic searches of the vital records of states and the National Death Index, supplemented by reports from family members or postal authorities. Data were analyzed from September 18, 2014, to March 27, 2016. MAIN OUTCOMES AND MEASURES:Total and cause-specific mortality. RESULTS:During 3?439?954 person-years of follow-up, 33?304 deaths were documented. After adjustment for known and suspected risk factors, dietary total fat compared with total carbohydrates was inversely associated with total mortality (hazard ratio [HR] comparing extreme quintiles, 0.84; 95% CI, 0.81-0.88; P?

SUBMITTER: Wang DD 

PROVIDER: S-EPMC5123772 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Association of Specific Dietary Fats With Total and Cause-Specific Mortality.

Wang Dong D DD   Li Yanping Y   Chiuve Stephanie E SE   Stampfer Meir J MJ   Manson JoAnn E JE   Rimm Eric B EB   Willett Walter C WC   Hu Frank B FB  

JAMA internal medicine 20160801 8


<h4>Importance</h4>Previous studies have shown distinct associations between specific dietary fat and cardiovascular disease. However, evidence on specific dietary fat and mortality remains limited and inconsistent.<h4>Objective</h4>To examine the associations of specific dietary fats with total and cause-specific mortality in 2 large ongoing cohort studies.<h4>Design, setting, and participants</h4>This cohort study investigated 83 349 women from the Nurses' Health Study (July 1, 1980, to June 3  ...[more]

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