Ontology highlight
ABSTRACT:
SUBMITTER: Giridhar PV
PROVIDER: S-EPMC5123825 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Giridhar Premkumar Vummidi PV Bell Sheila M SM Sridharan Anusha A Rajavelu Priya P Kitzmiller Joseph A JA Na Cheng-Lun CL Kofron Matthew M Brandt Eric B EB Ericksen Mark M Naren Anjaparavanda P AP Moon Changsuk C Khurana Hershey Gurjit K GK Whitsett Jeffrey A JA
Journal of immunology (Baltimore, Md. : 1950) 20161028 11
KIF3A, the gene encoding kinesin family member 3A, is a susceptibility gene locus associated with asthma; however, mechanisms by which KIF3A might influence the pathogenesis of the disorder are unknown. In this study, we deleted the mouse Kif3a gene in airway epithelial cells. Both homozygous and heterozygous Kif3a gene-deleted mice were highly susceptible to aeroallergens from Aspergillus fumigatus and the house dust mite, resulting in an asthma-like pathology characterized by increased goblet ...[more]