Ontology highlight
ABSTRACT:
SUBMITTER: Gao S
PROVIDER: S-EPMC5123835 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Gao Shuai S Gao Yanfei Y He Housheng Hansen HH Han Dong D Han Wanting W Avery Amy A Macoska Jill A JA Liu Xiaming X Chen Sen S Ma Fen F Chen Shaoyong S Balk Steven P SP Cai Changmeng C
Cell reports 20161001 4
Although well characterized as a transcriptional activator that drives prostate cancer (PCa) growth, androgen receptor (AR) can function as a transcriptional repressor, and high-level androgens can suppress PCa proliferation. The molecular basis for this repression activity remains to be determined. Genes required for DNA replication are highly enriched among androgen-repressed genes, and AR is recruited to the majority of these genes, where it rapidly represses their transcription. This activit ...[more]