Ontology highlight
ABSTRACT:
SUBMITTER: Houtz J
PROVIDER: S-EPMC5123838 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Houtz Jessica J Borden Philip P Ceasrine Alexis A Minichiello Liliana L Kuruvilla Rejji R
Developmental cell 20161101 3
Insulin secretion by pancreatic islet β cells is critical for glucose homeostasis, and a blunted β cell secretory response is an early deficit in type 2 diabetes. Here, we uncover a regulatory mechanism by which glucose recruits vascular-derived neurotrophins to control insulin secretion. Nerve growth factor (NGF), a classical trophic factor for nerve cells, is expressed in pancreatic vasculature while its TrkA receptor is localized to islet β cells. High glucose rapidly enhances NGF secretion a ...[more]