Dataset Information

Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.

ABSTRACT:

Objective

Both Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies.

Method

We used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD n = 15, ADHD n = 39, TD + ADHD n = 29, and healthy controls n = 53) as an in vivo method of evaluating glutamate concentrations in the fronto-striatal circuit. Spectra were collected on a 3 Tesla Siemens scanner from two voxels in each participant: the anterior cingulate cortex (ACC) and the left dorsal striatum. LC-model was used to process spectra and generate glutamate concentrations in institutional units. A one-way analysis of variance was performed to determine significant effects of diagnostic group on glutamate concentrations.

Results

We did not find any group differences in glutamate concentrations in either the ACC (F₍₃₁₃₂₎ = 0.97, p = 0.41) or striatum (F₍₃₁₂₁₎ = 0.59, p = 0.62). Furthermore, variation in glutamate concentration in these regions was unrelated to age, sex, medication use, IQ, tic, or ADHD severity. Obsessive-compulsive (OC) symptoms were positively correlated with ACC glutamate concentration within the participants with TD (rho = 0.35, p_uncorrected = 0.02).

Conclusion

We found no evidence for glutamatergic neuropathology in TD or ADHD within the fronto-striatal circuits. However, the correlation of OC-symptoms with ACC glutamate concentrations suggests that altered glutamatergic transmission is involved in OC-symptoms within TD, but this needs further investigation.

SUBMITTER: Naaijen J

PROVIDER: S-EPMC5124361 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.

Naaijen Jilly J Forde Natalie J NJ Lythgoe David J DJ Akkermans Sophie E A SE Openneer Thaira J C TJ Dietrich Andrea A Zwiers Marcel P MP Hoekstra Pieter J PJ Buitelaar Jan K JK

NeuroImage. Clinical 20161116

<h4>Objective</h4>Both Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies.<h4>Method</h4>We used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD <i>n</i> = 15, ADHD <i>n</i> = 39, TD + ADHD <i>n ...[more]

PMID: 27909683

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Project description:Intra-subject variability (ISV) is the most consistent behavioral deficit in Attention Deficit Hyperactivity Disorder (ADHD). ISV may be associated with networks involved in sustaining task control (cingulo-opercular network: CON) and self-reflective lapses of attention (default mode network: DMN). The current study examined whether connectivity supporting attentional control is atypical in children with ADHD. Group differences in full-brain connection strength and brain-behavior associations with attentional control measures were examined for the late-developing CON and DMN in 50 children with ADHD and 50 typically-developing (TD) controls (ages 8-12 years). Children with ADHD had hyper-connectivity both within the CON and within the DMN. Full-brain behavioral associations were found for a number of between-network connections. Across both groups, more anti-correlation between DMN and occipital cortex supported better attentional control. However, in the TD group, this brain-behavior association was stronger and occurred for a more extensive set of DMN-occipital connections. Differential support for attentional control between the two groups occurred with a number of CON-DMN connections. For all CON-DMN connections identified, increased between-network anti-correlation was associated with better attentional control for the ADHD group, but worse attentional control in the TD group. A number of between-network connections with the medial frontal cortex, in particular, showed this relationship. Follow-up analyses revealed that these associations were specific to attentional control and were not due to individual differences in working memory, IQ, motor control, age, or scan motion. While CON-DMN anti-correlation is associated with improved attention in ADHD, other circuitry supports improved attention in TD children. Greater CON-DMN anti-correlation supported better attentional control in children with ADHD, but worse attentional control in TD children. On the other hand, greater DMN-occipital anti-correlation supported better attentional control in TD children.

Dataset Information

Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.

Objective

Method

Results

Conclusion

Publications

Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.

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