Ontology highlight
ABSTRACT:
SUBMITTER: Wulsin AC
PROVIDER: S-EPMC5124765 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Wulsin Aynara C AC Herman James P JP Danzer Steve C SC
Frontiers in neurology 20161128
Status epilepticus (SE) induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and depression-like behavior. These observations have led to the hypothesis that HPA axis dysfunction may exacerbate SE-induced brain injury. To test this hypothesis, we used the mouse pilocarpine model of epilepsy to determine whether use of the gluco ...[more]