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Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women.

ABSTRACT: This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women.We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms.No significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p?=?0.61 and p?=?0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p?=?0.63 and p?=?0.24, respectively). All individuals were wild homozygotes for G241R polymorphism.This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.

SUBMITTER: Bessa NZ 

PROVIDER: S-EPMC5125152 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women.

Bessa Nathalie Zamagni NZ   Francisco Daniela de Oliveira DO   Andres Marina de Paula MP   Gueuvoghlanian-Silva Bárbara Yasmim BY   Podgaec Sergio S   Fridman Cintia C  

Journal of assisted reproduction and genetics 20160910 11

<h4>Purpose</h4>This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women.<h4>Methods</h4>We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms.<h4>Results</h4>No significant difference was observed in genotypic frequency between control  ...[more]

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