Dataset Information

Study design of the Maycoba Project: obesity and diabetes in Mexican Pimas.

ABSTRACT: To focus on the rationale and methods of the Maycoba Project.Study population included Mexican Pima Indians (MPI) and Blancos aged ?20-years, living in the village of Maycoba and surrounding area. Surveys in 1995 and 2010 included a medical history, biochemical and anthropomet- ric measurements. Additionally, socio- economic, physical activity, and dietary interviews were conducted. The 2010 study incorporated investigations on type 2 diabetes (T2D) and obesity-associated genetic alleles and human-envi- ronment changes.The study results are limited to demographic data and description of the eligible and ex- amined sample.This study may yield important information on T2D and obesity etiology in a traditional population exposed to environmental changes.

SUBMITTER: Urquidez-Romero R

PROVIDER: S-EPMC5125395 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Study design of the Maycoba Project: obesity and diabetes in Mexican Pimas.

Urquidez-Romero Rene R Esparza-Romero Julian J Chaudhari Lisa S LS Begay R Cruz RC Giraldo Mario M Ravussin Eric E Knowler William C WC Hanson Robert L RL Bennett Peter H PH Schulz Leslie O LO Valencia Mauro E ME

American journal of health behavior 20140501 3

<h4>Objective</h4>To focus on the rationale and methods of the Maycoba Project.<h4>Methods</h4>Study population included Mexican Pima Indians (MPI) and Blancos aged ≥20-years, living in the village of Maycoba and surrounding area. Surveys in 1995 and 2010 included a medical history, biochemical and anthropomet- ric measurements. Additionally, socio- economic, physical activity, and dietary interviews were conducted. The 2010 study incorporated investigations on type 2 diabetes (T2D) and obesity- ...[more]

PMID: 24636033

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Project description:This study was designed to quantify the relationship between the absence of heart failure risk factors in middle age and incident heart failure, heart failure-free survival, and overall survival.Quantification of years lived free from heart failure in the context of risk factor burden in mid-life may improve risk communication and prevention efforts.We conducted a pooled, individual-level analysis sampling from communities across the United States as part of 4 cohort studies: the Framingham Heart, Framingham Offspring, Chicago Heart Association Detection Project in Industry, and ARIC (Atherosclerosis Risk In Communities) studies. Participants with and without hypertension (blood pressure ?140/90 mm Hg or treatment), obesity (body mass index ?30 kg/m2), or diabetes (fasting glucose ?126 mg/dl or treatment), and combinations of these factors, at index ages of 45 years and 55 years through 95 years. Competing risk-adjusted Cox models, a modified Kaplan-Meier estimator, and Irwin's restricted mean were used to estimate the association between the absence of risk factors at mid-life and incident heart failure, heart failure-free survival, and overall survival.For participants at age 45 years, over 516,537 person-years of follow-up, 1,677 incident heart failure events occurred. Men and women with no risk factors, compared to those with all 3, had 73% to 85% lower risks of incident heart failure. Men and women without hypertension, obesity, or diabetes at age 45 years lived on average 34.7 years and 38.0 years without incident heart failure, and they lived on average an additional 3 years to 15 years longer free of heart failure than those with 1, 2, or 3 risk factors. Similar trends were seen when stratified by race and at index age 55 years.Prevention of hypertension, obesity, and diabetes by ages 45 years and 55 years may substantially prolong heart failure-free survival, decrease heart failure-related morbidity, and reduce the public health impact of heart failure.

Dataset Information

Study design of the Maycoba Project: obesity and diabetes in Mexican Pimas.

Publications

Study design of the Maycoba Project: obesity and diabetes in Mexican Pimas.

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