Ontology highlight
ABSTRACT:
SUBMITTER: Song D
PROVIDER: S-EPMC5125596 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Song Delu D Wilson Brooks B Zhao Liangliang L Bhuyan Rupak R Bandyopadhyay Mausumi M Lyubarsky Arkady A Yu Chen C Li Yafeng Y Kanu Levi L Miwa Takashi T Song Wen-Chao WC Finnemann Silvia C SC Rohrer Bärbel B Dunaief Joshua L JL
PloS one 20161128 11
Complement dysregulation plays a key role in the pathogenesis of age-related macular degeneration (AMD), but the specific mechanisms are incompletely understood. Complement also potentiates retinal degeneration in the murine light damage model. To test the retinal function of CD59a, a complement inhibitor, CD59a knockout (KO) mice were used for light damage (LD) experiments. Retinal degeneration and function were compared in WT versus KO mice following light damage. Gene expression changes, endo ...[more]