Ontology highlight
ABSTRACT:
SUBMITTER: Perwitasari O
PROVIDER: S-EPMC5125695 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Perwitasari Olivia O Johnson Scott S Yan Xiuzhen X Register Emery E Crabtree Jackelyn J Gabbard Jon J Howerth Elizabeth E Shacham Sharon S Carlson Robert R Tamir Sharon S Tripp Ralph A RA
PloS one 20161128 11
Influenza A virus (IAV) causes seasonal epidemics of respiratory illness that can cause mild to severe illness and potentially death. Antiviral drugs are an important countermeasure against IAV; however, drug resistance has developed, thus new therapeutic approaches are being sought. Previously, we demonstrated the antiviral activity of a novel nuclear export inhibitor drug, verdinexor, to reduce influenza replication in vitro and pulmonary virus burden in mice. In this study, in vivo efficacy o ...[more]