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Endoplasmic reticulum stress in beta cells and autoimmune diabetes.

ABSTRACT: Type 1 diabetes results from the autoimmune destruction of pancreatic ? cells, leading to insulin deficiency and hyperglycemia. Although multiple attempts have been made to slow the autoimmune process using immunosuppressive or immunomodulatory agents, there are still no effective treatments that can delay or reverse the progression of type 1 diabetes in humans. Recent studies support endoplasmic reticulum (ER) as a novel target for preventing the initiation of the autoimmune reaction, propagation of inflammation, and ? cell death in type 1 diabetes. This review highlights recent findings on ER stress in ? cells and development of type 1 diabetes and introduces potential new treatments targeting the ER to combat this disorder.

SUBMITTER: Clark AL

PROVIDER: S-EPMC5125892 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Endoplasmic reticulum stress in beta cells and autoimmune diabetes.

Clark Amy L AL Urano Fumihiko F

Current opinion in immunology 20161005

Type 1 diabetes results from the autoimmune destruction of pancreatic β cells, leading to insulin deficiency and hyperglycemia. Although multiple attempts have been made to slow the autoimmune process using immunosuppressive or immunomodulatory agents, there are still no effective treatments that can delay or reverse the progression of type 1 diabetes in humans. Recent studies support endoplasmic reticulum (ER) as a novel target for preventing the initiation of the autoimmune reaction, propagati ...[more]

PMID: 27718448

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