Unknown

Dataset Information

0

Overexpression of WDR79 in non-small cell lung cancer is linked to tumour progression.


ABSTRACT: WD-repeat protein 79 (WDR79), a member of the WD-repeat protein family, acts as a scaffold protein, participating in telomerase assembly, Cajal body formation and DNA double-strand break repair. Here, we first report that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung cancer (NSCLC). Knockdown of WDR79 significantly inhibited the proliferation of NSCLC cells in vitro and in vivo by inducing cell cycle arrest and apoptosis. WD-repeat protein 79 -induced cell cycle arrest at the G0/G1 phase was associated with the expression of G0/G1-related cyclins and cyclin-dependent kinase complexes. We also provide evidence that WDR79 knockdown induces apoptosis via a mitochondrial pathway. Collectively, these results suggest that WDR79 is involved in the tumorigenesis of NSCLC and is a potential novel diagnostic marker and therapeutic target for NSCLC.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC5125931 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3352848 | biostudies-literature
| S-EPMC6223208 | biostudies-literature
| S-EPMC6223209 | biostudies-literature
| S-EPMC6528891 | biostudies-literature
| S-EPMC2394471 | biostudies-other
| S-EPMC4919505 | biostudies-literature
| S-EPMC5729436 | biostudies-literature
| S-EPMC3778301 | biostudies-literature
| S-EPMC5710669 | biostudies-literature
| S-EPMC4622534 | biostudies-literature