Protective Capacity of the Human Anamnestic Antibody Response during Acute Dengue Virus Infection.

ABSTRACT: Half of the world's population is exposed to the risk of dengue virus infection. Although a vaccine for dengue virus is now available in a few countries, its reported overall efficacy of about 60% is not ideal. Protective immune correlates following natural dengue virus infection remain undefined, which makes it difficult to predict the efficacy of new vaccines. In this study, we address the protective capacity of dengue virus-specific antibodies that are produced by plasmablasts a few days after natural secondary infection. Among a panel of 18 dengue virus-reactive human monoclonal antibodies, four groups of antibodies were identified based on their binding properties. While antibodies targeting the fusion loop of the glycoprotein of dengue virus dominated the antibody response, two small

SUBMITTER: Xu M 

PROVIDER: S-EPMC5126370 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature