Dataset Information

Mammals in the MZNA Vertebrate Collection of University of Navarra, Spain.

ABSTRACT: In this paper five datasets are described that provide information about records of mammals in the Vertebrate Collection of the Museum of Zoology of the University of Navarra (MZNA-VERT). The datasets contain 3,466 records belonging to 20 species of mammals sampled across the transition zone between the Atlantic and Mediterranean biogeographical regions (north Iberian Peninsula). The datasets include both distributional data (georeferenced records) and basic biometric data of most of the vouchered specimens stored in the museum facilities. The samples originated mainly within research projects and PhD theses carried out in the former department of Zoology and Ecology of the University of Navarra between 1982 and 2011. The Darwin Core Archive Format datasets are accessible through GBIF.

SUBMITTER: Escribano N

PROVIDER: S-EPMC5126535 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Mammals in the MZNA Vertebrate Collection of University of Navarra, Spain.

Escribano Nora N Galicia David D Ariño Arturo H AH Escala Carmen C

ZooKeys 20161121 634

In this paper five datasets are described that provide information about records of mammals in the Vertebrate Collection of the Museum of Zoology of the University of Navarra (MZNA-VERT). The datasets contain 3,466 records belonging to 20 species of mammals sampled across the transition zone between the Atlantic and Mediterranean biogeographical regions (north Iberian Peninsula). The datasets include both distributional data (georeferenced records) and basic biometric data of most of the voucher ...[more]

PMID: 27917054

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Project description:BACKGROUND:Genetic testing for BRCA1/2 genes is widely used as a strategy to reduce incidence and morbidity of hereditary breast and ovarian cancer (HBOC). The purpose of this study is to analyse the demographic and molecular characteristics of BRCA germline mutations in Navarra, Spain, and to investigate the clinical profile of hereditary and sporadic breast cancer (BC) and ovarian cancer (OC) in the Community. METHODS:The study includes 1246 individuals assessed for BRCA1/2 genetic testing in Navarra, during 2000-2016, and a cohort of BC (n?=?4384) and OC (n?=?561) from the population-based Navarra Cancer Registry. Distribution and molecular characteristics of BRCA1/2 mutations, as well as, comparative analysis of the clinical course, pathologic features and overall survival (OS) of patients in different risk groups were investigated. RESULTS:BRCA mutation detection rate was 16%, with higher proportion (63%) of BRCA2 families. Nineteen per cent of mutations were recurrent, one of which, BRCA2 c.6024dupG, showed high association to OC. BRCA carriers had double risk (95% CI?=?1.04-4.33) of developing multiple malignancies than low risk families and were diagnosed at a much earlier age (16.6 and 11.7?years difference for BC and OC, respectively) when compared to the general population. For BC, BRCA carriers showed a more advanced histological stage, higher risk of bilateral neoplasms (OR?=?4.3; 95% CI?=?1.3-11.4, for BRCA2 carriers) and worse OS rate at 5-, 10- and 15- years, than women with sporadic tumors. For OC, over 70% of patients of all risk groups showed advanced stages at diagnosis, with the highest among BRCA1 carriers (91%). Furthermore, they also had higher probability of developing ovarian bilateral tumors (OR?=?7.8, 95% CI?=?1.7-55.7, for BRCA1 carriers) than the general population. Five-year OS rate was worse among women with sporadic OC than BRCA carriers, but it levelled out over the 15-year period. CONCLUSIONS:In addition to national similarities in the HBOC-BRCA1/2 associated mutational spectrum, we identified a recurrent BRCA2 pathogenic variant (c.6024dupG), highly associated to OC in Navarra. Carriers of BRCA1/2 mutations showed a more severe BC and OC phenotype and had a worse overall prognosis when compared to a large cohort of women with sporadic counterpart tumors.

Project description:mHealth researchers can now collect a wealth of data using “life tracking apps” (LTAs), which are smartphone applications that use mobile sensing to capture and summarise a multitude of data channels (e.g., location, movement, keyword use, sleep, exercise, and so on). The combined wealth of information can create digital signatures of individuals, which hold immense promise for mental health research and interventions by allowing new insights into moment-to-moment changes in behaviour and mental states. However, little is known about what a common research demographic (university students) thinks about these apps and what might factor into their decisions to participate in research using a LTA. This qualitative study ran five focus group sessions (21 students in total) to explore students’ experiences, beliefs, and opinions about LTAs to generate insights into what would make them more or less likely to participate in research involving LTAs. Transcripts were coded and examined for categories using qualitative content analysis. Important categories that emerged were privacy (although this varied based on the individual and data being collected), data security, inconvenience, intrusiveness, financial compensation, and the perceived nature of the research team responsible. On the basis of these categories, we derived seven key insights to increase student participation in research using LTAs: strengthen and communicate privacy and data security, design the app to be as convenient as possible to users, maximise passive data collection, think cautiously before tracking data perceived as “creepy” such as messages, offer suitable financial compensation, be transparent about goals and justification for data being collection to build trust, and attract participants by highlighting how the app can help them achieve their goals. With these insights, mHealth researchers can maximise their participant pool and improve this nascent and promising field.

Dataset Information

Mammals in the MZNA Vertebrate Collection of University of Navarra, Spain.

Publications

Mammals in the MZNA Vertebrate Collection of University of Navarra, Spain.

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