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Association between dioxin and cancer incidence and mortality: a meta-analysis.


ABSTRACT: The objective of the present study was to systematically assess the association between dioxin/2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and cancer incidence and mortality. Systematic literature searches were conducted until July 2015 in Pubmed, Embase and Cochrane library to identify relevant studies. A random-effects model was applied to estimate the pooled odds ratio (OR), risk ratio (RR), standard incidence ratio (SIR) or standard mortality ratio (SMR) for cancer incidence or mortality. In addition, dose-response, meta-regression, subgroup, and publication bias analyses were conducted. Thirty-one studies involving 29,605 cancer cases and 3,478,748 participants were included. Higher external exposure level of TCDD was significantly associated with all cancer mortality (pooled SMR?=?1.09, 95% CI: 1.01-1.19, p?=?0.04), but not all cancer incidence (pooled RR?=?1.01, 95% CI: 0.97-1.06, p?=?0.49). Higher blood level of TCDD was both significantly associated with all cancer incidence (pooled RR?=?1.57, 95% CI: 1.21-2.04, p?=?0.001) and all cancer mortality (pooled SMR?=?1.45, 95% CI: 1.25-1.69, p?

SUBMITTER: Xu J 

PROVIDER: S-EPMC5126552 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Association between dioxin and cancer incidence and mortality: a meta-analysis.

Xu Jinming J   Ye Yao Y   Huang Fang F   Chen Hanwen H   Wu Han H   Huang Jian J   Hu Jian J   Xia Dajing D   Wu Yihua Y  

Scientific reports 20161129


The objective of the present study was to systematically assess the association between dioxin/2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and cancer incidence and mortality. Systematic literature searches were conducted until July 2015 in Pubmed, Embase and Cochrane library to identify relevant studies. A random-effects model was applied to estimate the pooled odds ratio (OR), risk ratio (RR), standard incidence ratio (SIR) or standard mortality ratio (SMR) for cancer incidence or mortality. In  ...[more]

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