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Long intergenic non-coding RNA expression signature in human breast cancer.

ABSTRACT: Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several clinicopathological variables including receptor status and patient survival. We designed a two-stage study, including 1,000 breast tumor RNA-seq data from The Cancer Genome Atlas (TCGA) as the discovery stage, and RNA-seq data of matched tumor and adjacent normal tissue from 50 breast cancer patients as well as 23 normal breast tissue from healthy women as the replication stage. We identified 83 lincRNAs showing the significant expression changes in breast tumors with a false discovery rate (FDR)?

SUBMITTER: Zhang Y

PROVIDER: S-EPMC5126689 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Long intergenic non-coding RNA expression signature in human breast cancer.

Zhang Yanfeng Y Wagner Erin K EK Guo Xingyi X May Isaac I Cai Qiuyin Q Zheng Wei W He Chunyan C Long Jirong J

Scientific reports 20161129

Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several clinicopathological variables including receptor status and patient survival. We designed a two-stage study, including 1,000 breast tumor RNA-seq data from The Cancer Genome Atlas (TCGA) as the discovery stage, and RNA-seq data of matched tumor and adjacent n ...[more]

PMID: 27897201

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