Ontology highlight
ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC5126735 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cai Yongsong Y Xu Peng P Yang Le L Xu Ke K Zhu Jialin J Wu Xiaoqing X Jiang Congshan C Yuan Qiling Q Wang Bo B Li Yuanbo Y Qiu Yusheng Y
Scientific reports 20161129
Oxymatrine (OMT) is a type of alkaloid extracted from a traditional Chinese medicinal herb, Sophora flavescens. Although the antitumor activities of OMT have been observed in various cancers, there are no reports regarding the effects of OMT on human synovial sarcoma. In the present study, we analyzed the antitumor activities of OMT in SW982 human synovial sarcoma cells and determine whether high mobility group box protein 1 (HMGB1)-mediated autophagy was associated with its therapeutic effects. ...[more]