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BPTF Is Essential for T Cell Homeostasis and Function.

ABSTRACT: Bromodomain PHD finger transcription factor (BPTF), a ubiquitously expressed ATP-dependent chromatin-remodeling factor, is critical for epigenetically regulating DNA accessibility and gene expression. Although BPTF is important for the development of thymocytes, its function in mature T cells remains largely unknown. By specifically deleting BPTF from late double-negative 3/double-negative 4 stage of developing T cells, we found that BPTF was critical for the homeostasis of T cells via a cell-intrinsic manner. In addition, BPTF was essential for the maintenance and function of regulatory T (Treg) cells. Treg cell-specific BPTF deletion led to reduced Foxp3 expression, increased lymphocyte infiltration in the nonlymphoid organs, and a systemic autoimmune syndrome. These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.

SUBMITTER: Wu B

PROVIDER: S-EPMC5127169 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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BPTF Is Essential for T Cell Homeostasis and Function.

Wu Bing B Wang Yunqi Y Wang Chaojun C Wang Gang Greg GG Wu Jie J Wan Yisong Y YY

Journal of immunology (Baltimore, Md. : 1950) 20161031 11

Bromodomain PHD finger transcription factor (BPTF), a ubiquitously expressed ATP-dependent chromatin-remodeling factor, is critical for epigenetically regulating DNA accessibility and gene expression. Although BPTF is important for the development of thymocytes, its function in mature T cells remains largely unknown. By specifically deleting BPTF from late double-negative 3/double-negative 4 stage of developing T cells, we found that BPTF was critical for the homeostasis of T cells via a cell-in ...[more]

PMID: 27799308

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