Ontology highlight
ABSTRACT:
SUBMITTER: Colas RA
PROVIDER: S-EPMC5127279 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Colas Romain A RA Dalli Jesmond J Chiang Nan N Vlasakov Iliyan I Sanger Julia M JM Riley Ian R IR Serhan Charles N CN
Journal of immunology (Baltimore, Md. : 1950) 20161031 11
Maresin 1 (MaR1) is an immunoresolvent that governs resolution of acute inflammation, and its local metabolism in the context of infectious inflammation is of interest. In this study, we investigated the MaR1 metabolome in infectious exudates and its bioactions in regulating leukocyte responses in the context of bacterial infection. In Escherichia coli infectious exudates, MaR1 was temporally regulated with maximal levels at 4 h (2.2 ± 0.4 pg/lavage). In these exudates we also identified two nov ...[more]