Ontology highlight
ABSTRACT:
SUBMITTER: Junemann A
PROVIDER: S-EPMC5127317 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Junemann Alexander A Filić Vedrana V Winterhoff Moritz M Nordholz Benjamin B Litschko Christof C Schwellenbach Helena H Stephan Till T Weber Igor I Faix Jan J
Proceedings of the National Academy of Sciences of the United States of America 20161107 47
Phagocytosis and macropinocytosis are Ras-regulated and actin-driven processes that depend on the dynamic rearrangements of the plasma membrane that protrudes and internalizes extracellular material by cup-shaped structures. However, the regulatory mechanisms underlying actin assembly in large-scale endocytosis remain elusive. Here, we show that the Diaphanous-related formin G (ForG) from the professional phagocyte Dictyostelium discoideum localizes to endocytic cups. Biochemical analyses reveal ...[more]