Ontology highlight
ABSTRACT:
SUBMITTER: Artemenko Y
PROVIDER: S-EPMC5127353 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Artemenko Yulia Y Axiotakis Lucas L Borleis Jane J Iglesias Pablo A PA Devreotes Peter N PN
Proceedings of the National Academy of Sciences of the United States of America 20161107 47
Signal transduction pathways activated by chemoattractants have been extensively studied, but little is known about the events mediating responses to mechanical stimuli. We discovered that acute mechanical perturbation of cells triggered transient activation of all tested components of the chemotactic signal transduction network, as well as actin polymerization. Similarly to chemoattractants, the shear flow-induced signal transduction events displayed features of excitability, including the abil ...[more]