Ontology highlight
ABSTRACT:
SUBMITTER: Kwak H
PROVIDER: S-EPMC5127687 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kwak Hyeongil H Salvucci Ombretta O Weigert Roberto R Martinez-Torrecuadrada Jorge L JL Henkemeyer Mark M Poulos Michael G MG Butler Jason M JM Tosato Giovanna G
The Journal of clinical investigation 20161107 12
Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow. Stress signals from cancer and other conditions promote HSPC mobilization into circulation and subsequent homing to tissue microenvironments. HSPC infiltration into tissue microenvironments can influence disease progression; notably, in cancer, HSPCs encourage tumor growth. Here we have uncovered a mutually exclusive distribution of EPHB4 receptors in bone marrow sinusoids and ephrin B2 ligands in hematopoietic cells. We ...[more]