Early pregnancy vitamin D status and risk of preeclampsia.

ABSTRACT:

Background

Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia.

Methods

We assessed the effect of vitamin D supplementation (4,400 vs. 400 IU/day), initiated early in pregnancy (10-18 weeks), on the development of preeclampsia. The effects of serum vitamin D (25-hydroxyvitamin D [25OHD]) levels on preeclampsia incidence at trial entry and in the third trimester (32-38 weeks) were studied. We also conducted a nested case-control study of 157 women to investigate peripheral blood vitamin D-associated gene expression profiles at 10 to 18 weeks in 47 participants who developed preeclampsia.

Results

Of 881 women randomized, outcome data were available for 816, with 67 (8.2%) developing preeclampsia. There was no significant difference between tr

SUBMITTER: Mirzakhani H 

PROVIDER: S-EPMC5127689 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature