Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
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ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC5127695 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
Lee Jiyeon J Harris Alexis N AN Holley Christopher L CL Mahadevan Jana J Pyles Kelly D KD Lavagnino Zeno Z Scherrer David E DE Fujiwara Hideji H Sidhu Rohini R Zhang Jessie J Huang Stanley Ching-Cheng SC Piston David W DW Remedi Maria S MS Urano Fumihiko F Ory Daniel S DS Schaffer Jean E JE
The Journal of clinical investigation 20161107 12
Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form ribonucleoproteins to guide covalent modifications of ribosomal and small nuclear RNAs in the nucleus. Recent studies have also uncovered additional non-canonical roles for snoRNAs. However, the physiological contributions of these small RNAs are largely unknown. Here, we selectively deleted four snoRNAs encoded within the introns of the ribosomal protein L13a (Rpl13a) locus in a mouse model. Loss of Rpl13a snoRNAs altered mitochondria ...[more]
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