Ontology highlight
ABSTRACT:
SUBMITTER: Kar P
PROVIDER: S-EPMC5128683 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kar Pulak P Mirams Gary R GR Christian Helen C HC Parekh Anant B AB
Molecular cell 20161101 4
Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear. Here, we show that two Ca<sup>2+</sup>-dependent transcription factor isoforms, NFAT1 and NFAT4, require distinct sub-cellular InsP<sub>3</sub> and Ca<sup>2+</sup> signals for physiologically sustained activation. NFAT1 is stimulated by sub-plasmalem ...[more]