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Versatile Catalytic Hydrogenation Using A Simple Tin(IV) Lewis Acid.

ABSTRACT: Despite the rapid development of frustrated Lewis pair (FLP) chemistry over the last ten years, its application in catalytic hydrogenations remains dependent on a narrow family of structurally similar early main-group Lewis acids (LAs), inevitably placing limitations on reactivity, sensitivity and substrate scope. Herein we describe the FLP-mediated H₂ activation and catalytic hydrogenation activity of the alternative LA iPr₃ SnOTf, which acts as a surrogate for the trialkylstannylium ion iPr₃ Sn⁺ , and is rapidly and easily prepared from simple, inexpensive starting materials. This highly thermally robust LA is found to be competent in the hydrogenation of a number of different unsaturated functional groups (which is unique to date for main-group FLP LAs not based on boron), and also displays a remarkable tolerance to moisture.

SUBMITTER: Scott DJ

PROVIDER: S-EPMC5129554 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Versatile Catalytic Hydrogenation Using A Simple Tin(IV) Lewis Acid.

Scott Daniel J DJ Phillips Nicholas A NA Sapsford Joshua S JS Deacy Arron C AC Fuchter Matthew J MJ Ashley Andrew E AE

Angewandte Chemie (International ed. in English) 20161024 47

Despite the rapid development of frustrated Lewis pair (FLP) chemistry over the last ten years, its application in catalytic hydrogenations remains dependent on a narrow family of structurally similar early main-group Lewis acids (LAs), inevitably placing limitations on reactivity, sensitivity and substrate scope. Herein we describe the FLP-mediated H2 activation and catalytic hydrogenation activity of the alternative LA iPr3 SnOTf, which acts as a surrogate for the trialky ...[more]

PMID: 27774711

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