Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.
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ABSTRACT:
SUBMITTER: Omori H
PROVIDER: S-EPMC5129588 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.
Omori Hisayoshi H Ogaki Soichiro S Sakano Daisuke D Sato Mutsumi M Umeda Kahoko K Takeda Naoki N Nakagata Naomi N Kume Shoen S
FEBS letters 20160714 16
C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin- and pancreatic polypeptide-expressing cells of the endocrine. In th ...[more]
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