Ontology highlight
ABSTRACT:
SUBMITTER: Tang SS
PROVIDER: S-EPMC5129919 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Tang Shan-Shan SS Wang Hui-Fu HF Zhang Wei W Kong Ling-Li LL Zheng Zhan-Jie ZJ Tan Meng-Shan MS Tan Chen-Chen CC Wang Zi-Xuan ZX Tan Lin L Jiang Teng T Yu Jin-Tai JT Tan Lan L
Oncotarget 20160601 26
The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C (MEF2C) is regarded as modulator of amyloid-protein precursor (APP) proteolytic processing, in which amyloid-β (Aβ) is produced. A common single nucleotide polymorphism (SNP, rs190982) in MEF2C gene was identified to be related to late-onset Alzheimer's disease (LOAD) in Caucasians ...[more]