Ontology highlight
ABSTRACT:
SUBMITTER: Bullova P
PROVIDER: S-EPMC5130026 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Bullova Petra P Cougnoux Antony A Abunimer Luma L Kopacek Juraj J Pastorekova Silvia S Pacak Karel K
Oncotarget 20160601 26
Hypoxia is a common feature of solid tumors that activates a plethora of pathways, resulting in proliferation and resistance of cancer cells to radio- and chemotherapy. Pheochromocytomas/paragangliomas (PHEOs/PGLs) with mutations in the gene coding for the subunit B of succinate dehydrogenase (SDHB) are the most aggressive forms of the disease, which is partially due to their pseudohypoxic character, metabolic abnormalities, and elevated reactive oxygen species (ROS) levels. We investigated the ...[more]