Ontology highlight
ABSTRACT:
SUBMITTER: Gong D
PROVIDER: S-EPMC5130111 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Gong Danyang D Kim Yong Hoon YH Xiao Yuchen Y Du Yushen Y Xie Yafang Y Lee Kevin K KK Feng Jun J Farhat Nisar N Zhao Dawei D Shu Sara S Dai Xinghong X Chanda Sumit K SK Rana Tariq M TM Krogan Nevan J NJ Sun Ren R Wu Ting-Ting TT
Cell host & microbe 20161101 5
Nuclear mRNA export is highly regulated to ensure accurate cellular gene expression. Viral inhibition of cellular mRNA export can enhance viral access to the cellular translation machinery and prevent anti-viral protein production but is generally thought to be nonselective. We report that ORF10 of Kaposi's sarcoma-associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requi ...[more]