Ontology highlight
ABSTRACT:
SUBMITTER: Ghoshal A
PROVIDER: S-EPMC5130135 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20150625 2
Schizophrenia patients exhibit deficits in signaling of the M1 subtype of muscarinic acetylcholine receptor (mAChR) in the prefrontal cortex (PFC) and also display impaired cortical long-term depression (LTD). We report that selective activation of the M1 mAChR subtype induces LTD in PFC and that this response is completely lost after repeated administration of phencyclidine (PCP), a mouse model of schizophrenia. Furthermore, discovery of a novel, systemically active M1 positive allosteric modul ...[more]