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Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

ABSTRACT: In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism. Some of those methods are refinements of classic biochemical tools, whereas most others are recent additions from the powerful tools of molecular biology. The aim of this statement is to be useful to many and to do justice to a dynamic field of great complexity.

SUBMITTER: Taegtmeyer H

PROVIDER: S-EPMC5130157 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Taegtmeyer Heinrich H Young Martin E ME Lopaschuk Gary D GD Abel E Dale ED Brunengraber Henri H Darley-Usmar Victor V Des Rosiers Christine C Gerszten Robert R Glatz Jan F JF Griffin Julian L JL Gropler Robert J RJ Holzhuetter Hermann-Georg HG Kizer Jorge R JR Lewandowski E Douglas ED Malloy Craig R CR Neubauer Stefan S Peterson Linda R LR Portman Michael A MA Recchia Fabio A FA Van Eyk Jennifer E JE Wang Thomas J TJ

Circulation research 20160324 10

In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature ...[more]

PMID: 27012580

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Project description:Despite numerous advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains a leading cause of morbidity and mortality. Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have reported on the benefits of meditation. Meditation instruction and practice is widely accessible and inexpensive and may thus be a potential attractive cost-effective adjunct to more traditional medical therapies. Accordingly, this American Heart Association scientific statement systematically reviewed the data on the potential benefits of meditation on cardiovascular risk. Neurophysiological and neuroanatomical studies demonstrate that meditation can have long-standing effects on the brain, which provide some biological plausibility for beneficial consequences on the physiological basal state and on cardiovascular risk. Studies of the effects of meditation on cardiovascular risk have included those investigating physiological response to stress, smoking cessation, blood pressure reduction, insulin resistance and metabolic syndrome, endothelial function, inducible myocardial ischemia, and primary and secondary prevention of cardiovascular disease. Overall, studies of meditation suggest a possible benefit on cardiovascular risk, although the overall quality and, in some cases, quantity of study data are modest. Given the low costs and low risks of this intervention, meditation may be considered as an adjunct to guideline-directed cardiovascular risk reduction by those interested in this lifestyle modification, with the understanding that the benefits of such intervention remain to be better established. Further research on meditation and cardiovascular risk is warranted. Such studies, to the degree possible, should utilize randomized study design, be adequately powered to meet the primary study outcome, strive to achieve low drop-out rates, include long-term follow-up, and be performed by those without inherent bias in outcome.

Dataset Information

Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Publications

Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Similar Datasets

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