Ontology highlight
ABSTRACT:
SUBMITTER: Fontenas L
PROVIDER: S-EPMC5130175 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Fontenas Laura L De Santis Flavia F Di Donato Vincenzo V Degerny Cindy C Chambraud Béatrice B Del Bene Filippo F Tawk Marcel M
PLoS genetics 20161130 11
Axon ensheathment by specialized glial cells is an important process for fast propagation of action potentials. The rapid electrical conduction along myelinated axons is mainly due to its saltatory nature characterized by the accumulation of ion channels at the nodes of Ranvier. However, how these ion channels are transported and anchored along axons is not fully understood. We have identified N-myc downstream-regulated gene 4, ndrg4, as a novel factor that regulates sodium channel clustering in ...[more]