Ontology highlight
ABSTRACT:
SUBMITTER: Liang W
PROVIDER: S-EPMC5131274 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Liang Wenquan W Cai Aizhen A Chen Guozhu G Xi Hongqing H Wu Xiaosong X Cui Jianxin J Zhang Kecheng K Zhao Xudong X Yu Jiyun J Wei Bo B Chen Lin L
Scientific reports 20161201
The prognosis of gastric cancer remains poor due to clinical drug resistance. Novel drugs are urgently needed. Shikonin (SHK), a natural naphthoquinone, has been reported to trigger cell death and overcome drug resistance in anti-tumour therapy. In this study, we investigated the effectiveness and molecular mechanisms of SHK in treatment with gastric cancer. In vitro, SHK suppresses proliferation and triggers cell death of gastric cancer cells but leads minor damage to gastric epithelial cells. ...[more]