Ontology highlight
ABSTRACT:
SUBMITTER: Dekkers G
PROVIDER: S-EPMC5131652 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Dekkers Gillian G Plomp Rosina R Koeleman Carolien A M CA Visser Remco R von Horsten Hans H HH Sandig Volker V Rispens Theo T Wuhrer Manfred M Vidarsson Gestur G
Scientific reports 20161122
Immunoglobulin G (IgG) mediates its immune functions through complement and cellular IgG-Fc receptors (FcγR). IgG contains an evolutionary conserved N-linked glycan at position Asn297 in the Fc-domain. This glycan consists of variable levels of fucose, galactose, sialic acid, and bisecting N-acetylglucosamine (bisection). Of these variations, the lack of fucose strongly enhances binding to the human FcγRIII, a finding which is currently used to improve the efficacy of therapeutic monoclonal anti ...[more]