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Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata: a systematic review.

ABSTRACT: Renal angiomyolipomata associated with tuberous sclerosis complex are often bilateral, multiple and progressive. They cause significant morbidity and mortality in older children and adults. Surveillance and pre-emptive treatment reduce this risk. Recent research suggests treatment with mammalian target of rapamycin inhibitors is better at preventing bleeding, recurrence, and preserving renal function than percutaneous embolization.

SUBMITTER: Bissler JJ

PROVIDER: S-EPMC5131738 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata: a systematic review.

Bissler John J JJ Kingswood John C JC

Therapeutic advances in urology 20160406 4

Renal angiomyolipomata associated with tuberous sclerosis complex are often bilateral, multiple and progressive. They cause significant morbidity and mortality in older children and adults. Surveillance and pre-emptive treatment reduce this risk. Recent research suggests treatment with mammalian target of rapamycin inhibitors is better at preventing bleeding, recurrence, and preserving renal function than percutaneous embolization. ...[more]

PMID: 27928430

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