Ontology highlight
ABSTRACT:
SUBMITTER: Valverde R
PROVIDER: S-EPMC5131873 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Valverde Roberto R Ingram Jessica J Harrison Stephen C SC
Cell reports 20161101 8
The heterotetrameric Ndc80 complex establishes connectivity along the principal longitudinal axis of a kinetochore. Its two heterodimeric subcomplexes, each with a globular end and a coiled-coil shaft, connect end-to-end to create a ∼600 Å long rod spanning the gap from centromere-proximal structures to spindle microtubules. Neither subcomplex has a known function on its own, but the heterotetrameric organization and the characteristics of the junction are conserved from yeast to man. We have de ...[more]