Ontology highlight
ABSTRACT:
SUBMITTER: Tomic A
PROVIDER: S-EPMC5131914 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Tomić Adriana A Varanasi Pavankumar R PR Golemac Mijo M Malić Suzana S Riese Peggy P Borst Eva M EM Mischak-Weissinger Eva E Guzmán Carlos A CA Krmpotić Astrid A Jonjić Stipan S Messerle Martin M
PLoS pathogens 20161201 12
Development of an effective vaccine against human cytomegalovirus (HCMV) is a need of utmost medical importance. Generally, it is believed that a live attenuated vaccine would best provide protective immunity against this tenacious pathogen. Here, we propose a strategy for an HCMV vaccine that aims at the simultaneous activation of innate and adaptive immune responses. An HCMV strain expressing the host ligand ULBP2 for the NKG2D receptor was found to be susceptible to control by natural killer ...[more]